Abstract: OBJECTIVE To discuss the expression and the clinical significance of rheumatism disease 3 indicators to scarlet fever, so as to provide reference for clinical treatment. METHODS A total of 40 cases of children with scarlet fever in Handan infectious disease hospital from Jun. 2013 to Jun. 2015 were selected as scarlet fever groups, another 20 cases of children with normal physical examination as control group. ROC curve of three indicators in the diagnosis of scarlet fever were drawn and the critical value was determined. The clinical significances of anti streptolysin O(ASO), rheumatoid factor(RF) and C-reactive protein(CRP)to scarlet fever were analyzed. RESULTS RF and CRP in scarlet fever group were significantly higher than those of normal control group (P＜0.01), and ASO expresses were similar in two groups. According to the principle of taking the maximum from the ROC curve and sensitiveness + specificity, the critical value of ASO, RF and CRP were 35.1 IU/mL, 23.4 IU/mL and 4.65 mg/L in children with scarlet fever. CONCLUSION CRP is better than RF and ASO in the diagnosis, treatment and prognosis of scarlet fever, which has a high clinical value.