Abstract: OBJECTIVE To analyze the characteristics and risk factors of nosocomial infections in patients underwent general anesthesia surgery, in order to reduce the incidence of nosocomial infections. METHODS The clinical data of 1658 patients underwent surgery were retrospectively analyzed, who got treated in our hospital from Jan. 2012 to Dec. 2014. The incidence of nosocomial infections and infection sites were analyzed. The independent risk factors associated with nosocomial infections were analyzed. The data were under statistic analysis by SPSS 12.0. RESULTS The nosocomial infections were found in 148 cases out of 1658 patients, and the incidence of nosocomial infection was 8.93%. The respiratory tract and surgical sites were the most two common infectious sites, accounting for 66.22% and 27.70%, respectively. logistic regression analysis showed that the independent risk factors of nosocomial infections were age＞60, invasive operation, diabetes, long anesthesia time, repeated use of laryngoscope lens, filter using lime and sodium replacement (P<0.05). CONCLUSION The respiratory tract and surgical sites are easily infected sites in patients underwent general anesthesia surgery. And it is associated with a variety of risk factors, which must be paid more attention to, in order to prevent the occurrence of hospital infections.