Abstract: OBJECTIVE To analyze the incidences of nosocomial infections in patients with chronic heart failure, the distribution characteristics of pathogenic bacteria and the related risk factors, and to propose the corresponding intervention measures. METHODS A total of 500 patients with chronic heart failure in our hospital from Feb. 2013 to May 2015 were selected as the study objects. The occurrence of nosocomial infections in patients with chronic heart failure, and the distribution characteristics of pathogenic bacteria were analyzed. The related risk factors were analyzed by logistic regression analysis. Data were analyzed by SPSS 18.0. RESULTS A total of 20 cases from 500 cases of chronic heart failure patients got nosocomial infections, and the infection rate was 4%. There were 48 strains of pathogens detected, mainly gram-negative bacteria, accounting for 77.09%, followed by gram-positive bacteria 16.66%, fungi 6.25%. By logistic regression analysis, the independent risk factors of nosocomial infections in patients with chronic heart failure were age, heart function classification, combined with basic diseases, invasive operation, antibiotic prophylaxis and the time of hospitalization (P<0.05). CONCLUSION There are many risk factors to cause nosocomial infections in patients with chronic heart failure, according to which the corresponding interventions should be implemented actively, in order to reduce the incidence of nosocomial infections.