Abstract: OBJECTIVE To summarize the clinical feature, difficulties in diagnosis and treatment,and solutions of tuberculosis infection in post-solid organ transplantation patients. METHODS The clinical data of 38 patients with TB who occurring among SOT in organ transplant institution from Feb. 2002 to Oct. 2015 were retrospectively reviewed, and the clinical manifestations, laboratory and radiological results, treatment programs and prognosis were analyzed. RESULTS Thirty eight of 3093 SOT recipients developed TB, with the infection rate of 1.23%. The most frequent adverse reactions in anti-TB treatment were respectively liver damage(18.4%) and gastrointestinal symptoms (13.2%). Each patient was adopted with individual treatment. The following up were 1 month to 108 months. Twenty-nine cases were cured, 2 cases were being treated, 1 case was lost to follow-up, and 6 cases died, including 1 case died of tumor recurrence, 2 cases died of disseminated tuberculosis, 2 cases died of liver failure, and 1 case died of septic shock. CONCLUSION SOT recipients with a high incidence of TB, rapid development, clinical manifestations are not typical, and there are many difficulties in diagnosis and treatment. The treatment strategies should be chosen according to the transplantation organs and liver and kidney function. Diagnostic therapy against tuberculosis should be put into practice for the patients with suspicious tuberculosis.