Abstract: OBJECTIVE To study the effects of different mouthwash methods on oral infection of long-term psychiatric patients, in order to reduce oral infection of hospital psychiatric patients and improve their quality of life. METHODS A total of 100 long-term psychiatric patients in our hospital from Jan. 2014 to Dec. 2014 were selected for the study, 50 cases from Jan. to Jun. 2014 were selected as control group, and 50 cases from Jul. to Dec. 2014 were selected as observation group. Patients of control group used cetylpyridinium chloride gargle for mouthwash daily, and patients of observation group used the self Qiju soup for mouthwash daily mix formulated by the medlar, chrysanthemum, honeysuckle, and wood butterfly. The effects between the two groups were compared, and the data were analyzed by SPSS 17.0. RESULTS Totally 12 cases of oral infection were occurred in control group, with the infection rate of 24.00%, while 4 cases in observation group, with the infection rate of 8.00%, which was significantly lower than that of control group. The rates of halitosis, mouth ulcers, and bleeding gums of observation group were 12.0%, 10.0%, and 14.0%,, which were significantly lower than those of control group (P<0.05). CONCLUSION Self Qiju soup can effectively improve the oral hygiene of long-term psychiatric patients, reduce their oral infection rates, but can not impact the pathogens constituent ratio.