Abstract: OBJECTIVE To analyze the clinical effect of interferon-induced protein 10 in chronic hepatitis B virus infection, so as to provide scientific basis for clinical diagnosis and treatment of hepatitis B. METHODS A total of 56 healthy persons underwent medical examination in hospital from Jan. 2012 to Jan. 2015 were selected as the control group, and another 49 cases of patients in hospital for treatment of chronic hepatitis B at the same period were selected as test group. Clinical indicators of the two groups were compared, and the data were analyzed by SPSS 18.0. RESULTS The blood alanine aminotransferase ALT level in control group was (11.24±3.16) U/L, significantly lower than that of test group, and the blood IP-10 content of patients with chronic hepatitis B patients in test group was (191.08±85.78) pg/ml, significantly higher than that of control group (P<0.05). CONCLUSION Interferon-induced protein 10 participates in chronic HBV infection and aggravation, and plays a role in liver fibrosis and sclerosis deterioration process, but its ability for assessment of the patients condition and prognosis as laboratory parameters should be further studied.