Abstract: OBJECTIVE To explore the clinical efficacy of anti-infective sequential bronchoscopy high-frequent electro cautery in treatment of lung cancer combined with obstructive pneumonia, in order to provide reference for clinical diagnosis and treatment of lung cancer. METHODS A total of 80 patients with lung cancer combined with obstructive pneumonia from Jan. 2010 to Dec. 2014 in the hospital were selected. Sputum specimens were collected and pathogens were detected. The susceptibility testing was observed to analyze the resistance rate. Clinical indicators were compared before and after treatment. The data were analyzed by SPSS 18.0. RESULTS Totally 116 strains of pathogens were detected among 92 specimens of 80 patients, with the majority of 67 strains of gram-negative bacteria, accounting for 56.78%. Klebsiella pneumoniae, Pseudomonas aeruginosa was sensitive to meropenem and imipenem, with the drug resistance rates ＜15.00%. Compared with before treatment, the FEV1, FVC, KPS score and airway lumen diameter were significantly increased after treatment (P<0.05). CONCLUSION The clinical efficacy of anti-infective sequential bronchoscopy high-frequent electro cautery and chemotherapy in treatment of lung cancer combined with obstructive pneumonia is better, which can relieve obstructive pneumonia symptoms and improve the quality life of patients.