Abstract: OBJECTIVE To study the influence of compound danshen tablet combined with antiviral drug for the fibrosis indexes and granulofilocyte parameters of patients with hepatitis B cirrhosis,in order to provide evidence for the selection of treatment method. METHODS A total of 150 patients with hepatitis B cirrhosis in hospital from Dec. 2011 to Oct. 2014 were selected,and randomly divided into control group and observation group, with 75 cases in each group. Patients in control group were treated with conventional antiviral therapy,and in observation group were treated with compound danshen tablet combined with antiviral drug,then the fibrosis indexes and granulofilocyte parameters of the two groups were compared. The data were analyzed by SPSS 15.0. RESULTS The fibrosis indexes and granulofilocyte parameters of the two groups before the treatment had no significant differences,while the serum IV-C,LN,HA and PCⅢ of observation group at third,sixth and twelfth month after the treatment were all lower than those of control group,and the granulofilocyte parameters were all lower than those of control group too(P＜0.05). CONCLUSION The application effects of compound danshen tablet combined with nucleoside antiviral drugs in patients with hepatitis B cirrhosis are relatively better, and it has more active improvement role for the fibrosis indexes and granulofilocyte parameters of patients.