Abstract: OBJECTIVE To study the effect of interferon adjuvant therapy in children with recurrent respiratory tract infection and influence degree on the immune function of children,in order to achieve the goal of controlling the recurrent respiratory tract infection. METHODS A total of 60 cases of children with recurrent respiratory tract infection in our hospital from Jun. 2014 to Jul. 2015 were selected,and randomly divided into control group and observation group, with 30 cases in each group. The patients in control group were treated with conventional treatment of recurrent respiratory tract infection,and in observation group were treated with interferon based on the conventional treatment,then the total effective rates of the two groups were compared. RESULTS The total effective rate of observation group was 93.33%,which was significantly higher than 73.33% of control group; the eripheral blood T, B lymphocyte subsets and erythrocyte immune indexes at first,second and third course after the treatment were all better than those of control group,and the differences were all significant(P＜0.05). CONCLUSION The effect of interferon adjuvant therapy in children with recurrent respiratory tract infection are better,and its regulating effect for the immune function of children are prominent.