Abstract: OBJECTIVE To observe the Influence of Xuebijing injection on LA, PCT, CRP and hemodynamics in patients with septic shock, so as to provide a reference for treatment of septic shock. METHODS A total of 80 cases of patients with septic shock in our hospital from Jan. 2014 to Aug. 2014 were selected, and randomly divided into observation group and control group, with 40 cases in each group. The patients in the two groups were all given septic shock standardized treatment, and the patients in observation group at the same time were given the Xuebijing injection intravenous drip. The curative effects, the influence on LA, PCT, CRP and hemodynamics were compared. The data were analyzed by SPSS 19.0. RESULTS Compared with before treatment, the clinical indexes of observation group and control group were significantly decreased after treatment. The total effective rate of observation group was 92.50%, higher than 75.00% of control group (P<0.05). CONCLUSION Xuebijing injection for the treatment of septic shock can inhibit the body's inflammatory response, improve hemodynamic effect, and help to improve treatment efficacy.