Abstract: OBJECTIVE To study the diagnosis and treatment methods and effects for patients with nonfunctional pancreatic neuroendocrine tumors infection and to provide basis for improving clinical cure. METHODS Clinical data of 90 cases of nonfunctioning pancreatic neuroendocrine tumors co-infected patients who were treated in the hospital from Oct. 2014 to Dec. 2015 were analyzed. The patients were divided into two groups by means of random digits with 45 cases respectively in experimental and control group. The control group was given open surgery, while the experimental group were given minimally invasive surgery. Clinical treatment effects of the two groups were compared. RESULTS The enrolled 90 patients were treated with imageological examination, and the inspection positive rate of the top three were: CT, DSA and ultrasound with the positive rates of 81.1%, 71.1% and 61.1% respectively. The complication rate of experimental group was 11.1% which was significantly lower than 26.67% of the control group (P<0.05). CONCLUSION For patients with nonfunctional pancreatic neuroendocrine tumors combined with infection, the examination results with B ultrasound, CT or MRI and other imageological examination are favorable and they are reliable to diagnose patients with a better prognosis with minimal invasive surgery and less trauma, and they are worthy being widely applied.