Abstract: OBJECTIVE To investigate the clinical effects of different respiratory preparation methods of patients with gastrointestinal disease on preoperative pulmonary infection after surgery, so as to provide theoretical guidance for clinically reducing postoperative pulmonary infection complications. METHODS A total of 96 patients in the hospital for treatment of gastrointestinal diseases from Feb. 2002 to Dec. 2014 were selected, and randomly divided into control group and observation group, with 48 patients in each group. Before the surgery, patients of control group used only the inhalation method, while patients of observation group used breathing and sputum training on the basis of the inhalation method. It was observed in postoperative pulmonary infection. RESULTS Totally 7 cases of postoperative pulmonary infection occurred in control group, with pulmonary infection rate of 14.58%, while 2 cases of postoperative pulmonary infection occurred in observation group, with pulmonary infection rate of 4.16%, and there was significant difference between the two groups(P<0.05). Totally 9 cases of phlegm and 1 case of respiratory failure occurred in control group, while 1 case of phlegm and no case of respiratory failure were occurred in observation group. The complication rate of control group was higher than that of observation group (P<0.05). CONCLUSION The combined use of different respiratory preparation methods before the gastrointestinal can well control the probability of occurrence of postoperative pulmonary infection complications, which is worthy of clinical vigorously promoted.