Abstract: OBJECTIVE To investigate the effect of Helicobacter pylori (Hp) infection on the serum high-sensitivity C-reactive protein (hs-CRP), myeloperoxidase (MPO), lipoprotein-associated phospholipase A2 (Lp-PLA2) level and the severity in patients with coronary heart disease, so as to provide references for clinical diagnosis and treatment of coronary heart disease. METHODS A total of 165 cases of coronary heart disease patients from Dec. 2012 to Dec. 2013 in our hospital were chosen as the research objects. According to the ¹⁴C urea breath test results, patients were divided into Hp positive group (82 cases) and Hp negative group (83 cases). The hs-CRP, MPO, Lp-PLA2, white blood cell count and Gensini scores and other indicators for the objects were observed and compared. The data were analyzed by SPSS 19.0. RESULTS The hs-CRP, MPO, Lp-PLA2, white blood cell count and Gensini score of patients in Hp positive group were (18.34±6.65) mg / L, (250.45±38.45) μg/L, (228.34±49.56) μg/L, (8.29 ± 3.45) 10⁹/L and (59.43±5.55) points, which were significantly higher than patients in Hp negative group (P<0.05). CONCLUSION With the extent of Hp infection in patients with coronary artery disease, the patients serum inflammatory factors will rise, and the patients' conditions will be further intensified.