Abstract: OBJECTIVE To analyze the correlation of upper respiratory tract infection and coronary heart disease and cardiovascular events, so as to provide evidence for coronary heart disease diagnosis and treatment. METHODS A total of 60 cases of patients with coronary heart disease combined upper respiratory tract infection in our hospital from Oct. 2014 to Oct. 2015 were selected as infection group, another 60 patients with coronary artery disease but no upper respiratory tract infection in the same period as control group. The incidence of cardiovascular events was compared. The influencing factors of coronary heart disease mortality was explored. SPSS 17.0 was used for statistic analysis. RESULTS The incidence of heart failure was 11.7% and death incidence was 16.7% in infection group which were higher than the incidence of heart failure 1.7% and death incidence 6.7% in control group (P<0.05). Upper respiratory tract infection, acute myocardial infarction and old myocardial infarction were independent risk factors of death to patients with coronary heart disease, and the OR values were 3.8, 4.3 and 15.5. CONCLUSION Upper respiratory tract infection can decrease the serum high-density lipoprotein cholesterol and low density lipoprotein cholesterol in coronary heart disease patients and increase serum C-reactive protein levels, which also can increase the incidence of heart failure and death of coronary heart disease patients. Upper respiratory tract infection is an independent risk factor for coronary heart disease death.