Abstract: OBJECTIVE To analyze the surgery-related risk factors of surgical site infections after open heart to provide scientific and efficient solution strategy, in order to reduce surgical site infection after open heart surgery. METHODS A total of 258 patients undergoing open heart surgery in the hospital from Mar. 2012 to Mar. 2015 were selected, using retrospective survey method to give a analysis of the constitute of pathogens and related risk factors. SPSS 18.0 was used for data statistic analysis. RESULTS There were 9 cases of surgical site infections in 258 cases of open heart surgery, and the infection rate was 3.49%. A total of 14 strains of pathogens, mainly gram-negative bacteria 7 strains, accounting for 50.00%. Logistic regression analysis showed that age, time of surgery, blood loss amount during surgery, rational use of antimicrobial drugs, and other foreign objects implantation were the independent risk factors for postoperative surgical site infections occurred in patients(P<0.05). CONCLUSION There are many risk factors associated with surgical site infections after open heart surgery. Both patients and surgical procedures should be paid enough attention to improve surgical outcomes and reduce surgical site infection rates.