Abstract: OBJECTIVE To investigate the preventive effect of continuing nursing to patients with coronary heart disease and infection, received interventional treatment, so as to further provide theoretical guidance and basis for the post-discharge continuing nursing. METHODS A total of 100 cases of patients with coronary heart disease after interventional treatment in the hospital from Dec. 2013 to Nov. 2014 were selected for this study, who were randomly divided into control group and observation group. The 53 patients in the control group received routine care, and 53 cases in the observation group were given continuing nursing. The quality of life score and infection rate after control were compared and SPSS 16.0 was used for statistic analysis. RESULTS There was one case got infection in observation group, with infection rate of 1.89%, and 13 cases in control group (24.53%). The data differences in two groups were significant (P<0.05). In the comparison of 3, 6 and 12 months after interventional treatment quality of life scores, quality of life score and KPS score in observation group were both higher than those in control group (P<0.05). CONCLUSION After the interventional treatment to patients with coronary heart disease, continuing nursing can significantly improve the quality of life and self-care ability of patients, reduce the infection rate and chances of patients hospitalized again, worthy of clinical use.