Abstract: OBJECTIVE To explore the clinical diagnosis and treatment of pregnancy women with vulvovaginal Candida infection, so as to provide theoretical guidance and basis for the clinical treatment and diagnosis of gestational vulvovaginal Candida infection. METHODS A total of 204 patients from the hospital for treatment of vulvovaginal Candida infection during pregnancy from Jan. 2014-Jun. 2015 were selected as the study object, who were randomly divided into two groups, treatment group I and Ⅱ, with 102 cases of patients in each group. Treatment group I accepted routine therapy for vulvovaginal Candida infection, treatment group Ⅱ received special targeted treatment, and the infection status and therapeutic effect were compared in the two groups of patients under the different treatments. SPSS 16.0 was used for statistic analysis. RESULTS There were 81 cases of primary infection in the treatment group Ⅰ, accounting for 79.41%, treatment group Ⅱ 79 cases, accounting for 77.45%. The total efficiency was 73.53% in treatment group I and treatment group Ⅱ was 92.16%. Under comparison, data differences in two groups were significant (P<0.05). CONCLUSION Gestational vulvovaginal Candida infection patients compared with the general vulvovaginal Candida infection patients have its own peculiarities. Fungi drugs must be strictly prohibited in clinical treatment, so as to significantly reduce the impact of drug treatment on the unborn fetus.