Abstract: OBJECTIVE To investigate the clinical characteristics and preventive measures of nosocomial infections in patients with liver cancer after interventional chemotherapy, so as to provide reference for clinical treatment. METHODS A total of 208 cases of patients with liver cancer after interventional chemotherapy in hospital from Aug. 2014 to Jul. 2015 were selected. The clinical data of patients with nosocomial infections were investigated and analyzed by using questionnaire. The statistical analysis was conducted by SPSS19.0 software. RESULTS A total of 208 cases of patients with liver cancer after interventional chemotherapy, nosocomial infections occurred in 17 cases, with infection rate of 8.17%. The infection was mainly caused by pulmonary and abdominal infections, accounting for 35.29% and 23.53%. A total of 31 strains of pathogenic bacteria were detected from the 17 cases of nosocomial infection patients, mainly Escherichia coli, 10 strains, accounting for 32.25%. CONCLUSION In view of the nosocomial infections in patients with liver cancer treated by intervention chemotherapy, doctors and nurses should take active preventive measures to reduce the incidence of nosocomial infection.