Abstract: OBJECTIVE To investigate the clinical efficacy of moxifloxacin joint Xiyanping in the treatment of elderly patients with community acquired pneumonia and the effects on the serum levels of inflammatory cytokines and T lymphocyte subsets, so as to provide reference for clinical diagnosis and treatment of elderly patients with community acquired pneumonia. METHODS A total of 176 cases of community acquired pneumonia from Oct. 2010 to Dec. 2011 in our hospital were chosen. According to the treatment methods, they were divided into the study group and control group, and 88 cases in each group. The study group was taken with moxifloxacin joint Xiyanping treatment, and the control group was taken with Xiyanping treatment. The indicators and clinical outcomes for the two groups of patients after different treatments were observed and compared. SPSS 19.0 was used for data analysis. RESULTS After treatment, the CRP, PCT, sTREM-1and protein levels of periosteum in study group were better than control group; The total efficiency rate of the study group after treatment was 97.73%, significantly higher than 78.41% of the control group(P＜0.05). CONCLUSION Moxifloxacin joint Xiyanping can improve serum levels of inflammatory cytokines and T lymphocyte subsets for elderly patients with community acquired pneumonia, significantly improve the clinical effect of combined treatment of patients, and it is one of the ideal ways in clinical treatment.