Abstract: OBJECTIVE To analyze Helicobacter pylori (Hp) infection status and inflammatory factors and endothelial function changes before and after interventional therapy in patients with diabetes peripheral arterial diseases (PAD), so as to provide references for the treatment of diabetic PAD. METHODS A total of 120 cases of patients in hospital were selected from Jan. to Aug. 2015, and divided into PAD group and control group according to the disease, with each group of 60 cases. The Hp infection rate and inflammatory factors of the two groups were compared. The data were analyzed by SPSS 19.0. RESULTS of There were 37 cases in PAD group and 22 cases in control group of Hp positive, with the infection rates of 61.67% and 36.67%, and the difference was significant (P<0.05). The hs-CRP, vWF and ET levels of patients in PAD group were higher than those in control group at admission (P<0.05). The hs-CRP, vWF, ET level in 24h after operation was higher than at admission in patients of PAD group. CONCLUSION Diabetic PAD patients have higher infection rate of HP than simple diabetes, their inflammation and endothelial dysfunction are more obvious, and intervention surgery can aggravate the damage of endothelial function and inflammatory response.