Abstract: OBJECTIVE To investigate the effect of the prevention and control intervention of donor-derived infections（DDIs） in reducing the incidence of nosocomial infection, carbapenem-resistant Klebsiella pneumoniae（CRKP） infections, and CRKP infection rates caused by DDIs in solid organ transplant recipients. METHODS A retrospective cohort study was used to select all patients who underwent organ transplantation at Shanghai Changhai Hospital as the research subjects. From Jun. 2016 to Dec. 2017, 586 patients were collected as the control group, and conventional hospital infection prevention and control measures were implemented. From Jan. 2018 to Feb. 2019, 289 patients were selected as intervention group. DDI prevention and control interventions were implemented from the three aspects including donor infection status assessment and decision-making organ selection, infection prevention and control during donor maintenance, and prevention and control of recipients after receiving high-risk donor organ transplantation.The incidence of nosocomial infection in patients with solid organ transplantation before and after intervention, the proportion of CRKP infection in nosocomial infection patients, the percentage of CRKP infection caused by DDI, and the mortality of CRKP infection patients were observed and compared. RESULTS The incidence of nosocomial infection was 6.23%（18/289） in the intervention group, lower than that in control group 9.22%（54/586）（P=0.131）. CRKP infection rate was 0.35%（1/289） in the intervention group, lower than that in control group 1.71%（10/586）（P=0.169）.The proportion of CRKP infection in nosocomial infections was 5.56%（1/18） in the intervention group, lower than that in control group 18.52%（10/54）（P=0.344）. The proportion of CRKP infection caused by DDI was 0% in the intervention group, lower than that in control group（80.00%）（P=0.273）. The mortality of patients due to CRKP infection was 0% in the intervention group, lower than that in control group（40.0%）（P＞0.999）. CONCLUSION The DDI prevention and control interventions can effectively reduce the incidence of nosocomial infections, CRKP infection rate, the proportion of CRKP infection in patients with solid organ transplants, especially CRKP infections caused by DDI mortality in CRKP infected patients.