Abstract: Donor-derived infection is a major challenge in solid organ transplantation. At present, most solid organ donors in China are patients staying in ICU and at high risk of multidrug-resistant organism infection and colonization. The donor-derived infections caused by these can threaten the life safety of recipients in serious cases. In the transplatation work, efforts should be made not only to avoid the risk of donor-derived infections, but also make full use of scarce donor organs. Therefore, it is necessary to strengthen information communication and multi-disciplinary collaboration for the purpose to process the monitoring and proactively monitor the potential risk of infection from the source. The potential donors should be maintained to prevent infection, and critically assessed for the infection status before organ procurement. Appropriate and effective control and prevention of infection should be put into practice for recipients after transplantation.