Abstract: OBJECTIVE To investigate the effects of pulmonary infection on oxidative stress, TF and TFPI-1 in patients with severe craniocerebral trauma. METHODS A total of 156 patients with severe craniocerebral injury hospitalized in Rizhao Hospital of traditional Chinese medicine from Sep. 2016 to Feb. 2019 were selected as the study subjects. Among them, a total of 35 patients with pulmonary infection were assigned to infection group and 121 patients without pulmonary infection were assigned to control group. The pathogenic results of patients in the infection group were evaluated, and the changes of MDA, SOD, cat, TF, TFPI-1 and inflammatory factors were measured and compared between the two groups. RESULTS A total of 41 strains of pathogenic bacteria were detected in patients with severe craniocerebral trauma and pulmonary infection, among which Gram-negative bacteria accounted for 65.85%（27/41）, Gram-positive bacteria accounted for 26.83%（11/41）, and fungi accounted for 7.32%（3/41）. The levels of MDA of the infected group was（19.11±3.09）U/ml, significantly higher than that of the control group, SOD and CAT of the infected group was（17.68±2.89）U/L and（21.55±1.89）U/ml, respectively, significantly lower than those in the control group（P＜0.01）. The levels of TF and TFPI-1 in the infected group was（47.09±9.08）ng/L and（40.95±8.16）μg/L, respectively, significantly higher than those in the control group（P＜0.001）. The levels of IL-4 and IL-6 was（86.46.09±10.81） ng/L and（15.35±1.52）pg/ml, respectively, in the infected group, significantly higher than those in the control group（P＜0.001）. CONCLUSION Gram-negative bacteria were the main pathogens in patients with severe craniocerebral trauma complicated with pulmonary infection, and pulmonary infection caused disorders of oxidative stress in the body, which had a profound impact on the changes of TF and TFPI-1 levels. Defining the cause of postoperative infection is helpful to further improve the prognosis of patients.