Abstract: OBJECTIVE To investigate the predictive value of earlyglycemic parameters in patients with acute stroke combined with stress-induced hyperglycemia on nosocomial infection. METHODS A total of 82 patients with acute stroke combined with stress hyperglycemia and nosocomial infection treated in Ningbo Huamei Hospital of the University of Chinese Academy of Sciences from Jun. 2017 to May 2019 were selected as the infection group, during the same period, 94 patients with acute stroke complicated with stress hyperglycemia who did not develop nosocomial infection were selected as the non-infection group. Blood glucose parametersfasting blood glucose（FBG）, average blood glucose（AG）, glycemic instability index（GLI）, fasting insulin（FINS）, insulin resistance index（HOMA-IRI）, insulin secretion index（HOMA-IFI）, and C-reactive protein（CRP） at the time of enrollment（T0）, the diagnosis of nosocomial infection 24 to 72 hours（T1）, and the time of anti-infection treatment 5-7 days（T2）,of infection group were monitored, and blood glucose parameters and CRP at the above-mentioned time points of non-infection group were simultaneously measured. The correlation of the characteristics of ROC curve, blood sugar parameters and CRP were analyzed so as to determine the value of blood sugar parameters for early prediction of nosocomial infection in patients with acute stroke combined with stress hyperglycemia. RESULTS At the time of T0, the levels of FBG, AG, GLI, FINS, HOMA-IRI and CRP in the infected group were（9.72±1.84） mmol/L,（10.01±2.01） mmol/L（3.10±2.00）（mmol/L）²/（h·d）,（16.10±4.25） μIU/ml,（5.91±1.44）, and（67.00±9.20）mg/L, respectively, significantly higher than those in the uninfected group, and HOMA-IFI was（139.60±11.00）%), significantly lower than those in the uninfected group（P＜0.05）. The levels of FBG, AG, GLI, FINS, HOMA-IRI and CRPwere（11.12±2.00）mmol/L,（13.01±1.03）mmol/L,（4.77±2.20）（mmol/L）²/（h·d）,（17.40±4.83）μIU/ml,（6.37±1.96）, and（75.50±8.78）mg/L, respectively, in patients with moderate to severe infection, significantly higher than those in patients with mild infection, and HOMA-IFI was（113.50±9.70）%, significantly lower than those in patients with mild infection（P＜0.05）. At the time of T0, T1, T2, the FBG, AG, GLI, FINS, HOMA-IRI and CRP in the infected group first increased and then decreased, while HOMA-IFI decreased and then increased significantly（P＜0.05）. The levels of FBG, AG, GLI, FINS, HOMA-IRI were positively correlated with CRP, while HOMA-IFI was negatively correlated with CRP（P＜0.05）. CONCLUSION The changes of blood glucose parameters had the value in early prediction of nosocomial infection in patients with acute stroke combined with stress-induced hyperglycemia, providing new ideas for clinical prevention and control of infection.