Abstract: OBJECTIVE To analyze the influencing factors of perceived discrimination between HIV-infected persons and AIDS patients（PLWHA）. METHODS Totally 80 PLWHA patients were selected from the outpatient department of nosocomial infectious diseases in the Third Affiliated Hospital of Zunyi Medical University from May 2016 to Jun. 2018 using a convenience sampling method. All patients were measured by Berger HIV Perceived Discrimination Scale to analyze their perceived discrimination level. RESULTS Factors affecting the level of perceived discrimination include gender, education level, CD₄ cell count, conscious health status and whether to inform others of the illness of PLWHA. The perceptual discrimination scores of 80 PLWHA patients, including negative self-impression, individualized discrimination, concern about public attitudes and fear of publicity, all of which were above the middle level, and the highest average score was fear of publicity:（3.06±0.45）. The highest score of 80 PLWHA Perceived Discrimination Scale was "For people who need to tell the condition, they need to be carefully considered before making a decision". Stepwise regression analysis showed that sexual transmission, poor self-perceived health status, unknown to relatives and family members, and female PLWHA had high level of perceived discrimination levels. CONCLUSION PLWHA’s perceptual discrimination level was above average, and there were many influencing factors of perceptual discrimination. It is necessary to provide corresponding measures to effectively reduce PLWHA’s perceived discrimination level.