Abstract: OBJECTIVE To observe the clinical effect of nebulized inhalation of budesonide suspension on treatment of children with acute infectious laryngitis so as to provide guidance for reasonable clinical use of antibiotics. METHODS A total of 120 children with conformed acute infectious laryngitis who were treated in the pediatrics department from Oct 2014 to Sep 2015 were recruited as the study objects and randomly divided into the observation group with 60 cases and the control group with 60 cases.Both groups were given the conventional supportive treatment and symptomatic treatment.The observation group was treated with nebulized inhalation of budesonide suspension, and the control group was treated with dexamethasone. RESULTS The time of disappearance of dyspnea, throat sound, cough, or hoarseness was significantly shorter in the observation group than in the control group (P＜0.05).The total effective rate of treatment of the observation group was 98.33%, significantly higher than 86.67% of the control group (P＜0.05).The incidence rate of adverse reactions was 6.67% in the observation group, 8.33% in the control group, and there was no significant difference. CONCLUSION The nebulized inhalation of budesonide suspension can achieve significant clinical effect on treatment of the acute infectious laryngitis, with incidence of adverse reactions low, the time of disappearance of clinical symptoms short.