Abstract: OBJECTIVE To explore the clinical efficacy of VSD in treatment of trauma infections in orthopedics department so as to provide guidance for clinical treatment. METHODS A total of 60 patients with trauma infections who were treated in the department of orthopedics from Sep 2013 to Mar 2013 were recruited as the study objects and randomly divided into the experimental group and the control group, with 30 cases in each. The clinical efficacy was observed and compared between the two groups of patients, and the statistical analysis of data was performed with the use of SPSS 13.0 software. RESULTS The total effective rate of treatment of the experimental group was 93.4%, significantly higher than 70.0% of the control group (P<0.05). The healing time and length of hospital stay were significantly shorter in the experimental group than in the control group (P<0.05). The incidence rate of complications was 20.0% in the experimental group, significantly lower than 46.7% in the control group (P<0.05). CONCLUSION The VSD can achieve significant efficacy in treatment of the patients with trauma infections in the department of orthopedics, remarkably shorten the healing time and length of hospital stay, and reduce the frequency of drug dressing; it is conducive to the rehabilitation of the patients and significantly reduce the incidence rate of complications induced by the infections.