Abstract: OBJECTIVE To set up the standard operating procedure (SOP) for treatment of power instruments in central sterile supply department, adopt the whole process quality control, and implement the specialized operation and management so as to improve the quality of supply of the power instruments and avoid the risk of infections induced by the supply of the instruments. METHODS In Nov, 2014, a total of 910 power instruments were collected from the hospital before the implementation of SOP, and the cleaning and disinfection of the instruments were carried out according to the standards of management of surgical instruments; totally 844 power instruments that were used for surgeries and treated with SOP in Jan 2015 were recruited as the study objects. The quality of work was observed and compared before and after the implementation of SOP, and the obtained data were statistically analyzed by using SPSS 16.0 software. RESULTS Totally 43 power instruments were unqualified before the implementation of SOP, with the unqualified rate 4.73%; totally 2 power instruments were unqualified after the implementation of SOP, with the unqualified rate 0.24%, and there was significant difference (P＜0.01). CONCLUSION It is necessary to establish the standard operating procedure for treatment of the power instruments in the central sterile supply department, adopt the professional operation and whole process quality control, make the staff focus on the specialized instruments, and reflect the detailed management so as to improve the quality of supply of the power instruments, prevent nosocomial infections, and ensure the safety of the patients.