Abstract: OBJECTIVE To explore the distribution of pathogens causing nosocomial infections in patients with coronary heart disease, analyze the related risk factors, and put forward the prevention measures so as to reduce the incidence of the nosocomial infections. METHODS A total of 1 220 patients with coronary heart disease who were hospitalized from Feb 2012 to Dec 2014 were enrolled in the study, then the clinical data of the patients were analyzed, the bacterial culture was carried out for the secretion specimens obtained from the patients with nosocomial infections, the distribution of pathogens causing the nosocomial infections and the related risk factors were observed, and the statistical analysis of data was performed with the use of SPSS 18.0 software. RESULTS Of the 1 220 patients, 136 patients had nosocomial infections with the infection rate 11.15%, of whom 43.38% had respiratory tract infections, 27.21% had abdominal infections, and 11.03% had gastrointestinal tract infections. Totally 140 strains of pathogens were isolated, of which 37 (26.43%) were Klebsiella pneumoniae, 26 (18.57%) were Escherichia coli, 21 (15.00%) were Acinetobacter baumannii, and 17 (12.14%) were Staphylococcus aureus. The logistic regression analysis showed that the risk factors for the nosocomial infections in the patients with coronary heart disease included the age, complication of underlying diseases, use of antibiotics, length of hospital stay, and invasive operation (P<0.05). CONCLUSION It is an effective way to improve the immunity of the coronary heart disease patients of their own, simultaneously treat the coronary heart disease and underlying diseases, reduce invasive procedures, shorten the length of hospital stay, reasonably use antibiotics, and take appropriate interventions according to the risk factors for the nosocomial infections so as to control the nosocomial infections in the patients with coronary heart disease.