Abstract: OBJECTIVE To observe the effect of fiberoptic bronchoscopy lavage on treatment of patients with severe pulmonary infections and analyze the impact on prognosis so as to reduce the incidence of nosocomial infections. METHODS A total of 114 patients with severe pulmonary infections who were treated in hospitals from Sep 2012 to Sep 2015 were enrolled in the study and randomly divided into the observation group and the control group, with 57 cases in each. The control group was given the conventional treatment, while the observation group was treated with additional fiberoptic bronchoscopy lavage based on the conventional treatment. The clinical efficacy, hospitalization-related indicators, and clinical sings were observed and compared between the two groups after the treatment for 7 days, and the incidence of adverse reactions was analyzed. RESULTS The total effective rate of the observation group was 94.74%, the control group 82.46%, and there was significant difference (P＜0.05). The time of recovery of body temperature, time of disappearance of pulmonary rales, and length of hospital stay were significantly shorter in the observation group than in the control group (P＜0.05). The body temperature and white blood cell counts of the observation group were respectively lower than those of the control group on Day 7 of treatment (P＜0.05). In the observation group, there were 11 patients with sinus tachycardia with concurrent reduction of blood oxygen saturation and 5 patients with severe cyanosis complicated with decreased blood oxygen saturation during the treatment. CONCLUSION The fiberoptic bronchoscopy lavage can achieve significant effect on treatment of the patients with severe pulmonary infections and contribute to the improvement of prognosis.