Abstract: OBJECTIVE To explore the application of monitoring indicators of quality management in the quality management in central sterile supply department, ensure the safety of recyclable instruments, and improve the work efficiency. METHODS From May 2012 to Apr 2013, a total of 600 surgical instrument packages were enrolled in the study, then the quality monitoring indicators were determined, the quality monitoring was carried out by specially-assigned persons based on the quality monitoring indicators, the problems existing in the quality management were scientifically analyzed, and the operation mechanism of quality control was established. RESULTS Based on the quality control team, quality control circle team, and quality control QQ group, the causes of the problems in the quality management were analyzed every month by using fishbone diagram so as to solve the problems in a timely manner, formulate the rectification measures, continuously improve the quality of the central sterile supply department, and improve the work efficiency. As compared with the quality management before the quality management indicators were applied, the incidence rate of adverse reactions was decreased by 60.00%, and the qualified rate of cleaning of instruments was increased by 1.78%. CONCLUSION It is necessary to establish the quality monitoring indicator system and reflect the status of quality actually and objectively through the data so as to provide scientific basis for improvement of workflows, work efficiency, and continuous quality improvement.