Abstract: OBJECTIVE To explore the clinical characteristics of the hepatitis B liver cirrhosis patients with bacterial infection-induced hepatic encephalopathy so as to provide guidance for improvement of clinical efficacy. METHODS A total of 40 hepatitis B liver cirrhosis patients with bacterial infection-induced hepatic encephalopathy who were treated in the hospital from Jan 2015 to Aug 2015 were enrolled in the study and set as the experimental group, meanwhile, 40 patients with single hepatitis B liver cirrhosis were assigned as the control group.The biochemical indicators such as the blood ammonia, serum albumin, and transaminase were detected at admission to the hospital; the clinical characteristics of the hepatitis B liver cirrhosis patients with bacterial infection-induced hepatic encephalopathy were observed. RESULTS The level of serum albumin of the experimental group was significantly lower than that of the control group (P＜0.05).The levels of blood ammonia, alanine aminotransferase, total bilirubin, creatinine, and white blood cells as well as international normalized ratio were significantly higher in the experimental group than in the control group (P＜0.05).There was significant difference in the grade of hepatic encephalopathy among the patients with different sites of infections in the experimental group (P＜0.05); there was significant difference in the grade 3, 4, 1, or 2 hepatic encephalopathy among the patients with peritonitis, respiratory tract infections, urinary tract infections, and skin soft tissue infections (P＜0.05). CONCLUSION The bacterial infection-induced hepatic encephalopathy may exacerbate the illness condition of the patients with hepatitis B liver cirrhosis and lead to greater damage to the liver; it is necessary to pay attention during the clinical treatment so as to reduce the mortality rate.