Abstract: OBJECTIVE To investigate the prevalence of TORCH-IgM infection in children aged from 0 to 1 year old and analyze the characteristics so as to provide theoretical basis for clinical diagnosis and treatment. METHODS A total of 1 754 children aged no more than 1 year old who were treated in the hospital from May 2014 to Nov 2014 were recruited as the study objects, then the serum TORCH-IgM antibody was detected by using chemiluminescence method, the prevalence and characteristics of the TORCH-IgM infection in this age group of children were observed, the correlation between the infection and the month of age as well as the types of clinical diseases were explored, and the statistical analysis of data was performed with the use of SPSS17.0 software. RESULTS The serum TORCH-IgM was detected positive in 266 of 1 754 children, with the positive rate 15.17%; the positive rates of human cytomegalovirus (HCMV)-IgM, herpes simplex virus (HSV)-IgM, rubella virus (RV)-IgM, and toxoplasma (TOX)-IgM were 8.72%, 3.82%, 2.79%, and 0.06%, respectively. Totally 4 children were complicated with infections with two species of pathogens, with the infection rate 0.23%. The major clinical diseases in the TORCH-positive children included the hepatitis syndrome, jaundice, upper respiratory tract infection, bronchopneumonia, fever of unknown origin, and cerebral injury syndrome. CONCLUSION The TORCH infection is prevalent in the children aged from 0 to 1 year old, the HCMV infection is dominant, the TOX infection is rare, and the concurrent infection exists.