Abstract: OBJECTIVE To explore the effectiveness of blood transfusion in treatment of patients with septic shock so as to provide guidance for treatment of the patients with septic shock. METHODS A total of 60 patients with septic shock who were hospitalized for treatment from Jan 2010 to Jun 2015 were enrolled in the study and randomly divided into the blood transfusion group and the non-blood transfusion group, with 30 cases in each.The enrolled patients were given the basic treatments, including the treatment of primary diseases, correction of acidosis and electrolyte disorder, anti-infection, diuresis, and cardiac foundation treatment; the blood transfusion group was treated with transfusion of whole blood for 200-400 ml at the same time.The total volume of fluids, urine output per hour, central venous pressure (CAP), mean arterial pressure (MAP), cardiac output (CO), and ventricular end-diastolic volume index (EDVI) were recorded after the recovery for 24 hours; the changes of the levels of serum procalcitonin (PCT) and C-reactive protein (CRP) were observed before the recovery and after the recovery for 3 days, and the incidence of pulmonary edema and mortality rate in 28 days were analyzed. RESULTS The urine output per hour, CVP, MAP, and EDVI of the two groups were improved more significantly after the recovery for 24 hours than before the recovery (P＜0.05); the total volume of fluids of the blood transfusion group was less than that of the non-blood transfusion group after the recovery for 24 hours (P＜0.05); the urine output per hour of the blood transfusion group was more than that of the non-blood transfusion group (66.08±54.83)ml(P＜0.05).The levels of serum PCT and CRP of the two groups declined more remarkably after the recovery for 3 days than before the recovery (P＜0.05); the levels of serum PCT and CRP of the blood transfusion group were lower than those of the non-blood transfusion group after the recovery for 3 days.The incidence rate of pulmonary edema was 6.67% in the blood transfusion group, 13.33% in the non-blood transfusion group, and there was no significant difference.The mortality rate in 28 days was 0 in the blood transfusion group, 16.67% in the non-blood transfusion group, and there was significant difference (P＜0.05). CONCLUSION The patients with septic shock can be treated with appropriate blood transfusion on the basis of conventional fluid recovery, which may reduce the total volume of transfusion, enhance the body' s capability to resist inflammations, and reduce the mortality rate.