Abstract: OBJECTIVE To explore the distribution of pathogens causing postoperative surgical site infections in patients undergoing artificial hip replacement surgery and analyze the related risk factors so as to reduce the incidence of postoperative infections in the patients undergoing the artificial hip replacement surgery. METHODS The clinical data of 1 010 patients who underwent the hip replacement surgery from Apr 2010 to Mar 2015 were retrospectively analyzed, then the distribution of the pathogens causing the postoperative surgical site infections was observed, the logistic regression analysis was conducted for the related risk factors for the infections, and the statistical analysis was performed with the use of SPSS15.0 software. RESULTS The postoperative surgical site infections occurred in 30 of 1 010 patients, with the infection rate 2.97%.A total of 19 strains of pathogens were isolated, including 14 (73.68%) strains of gram-positive bacteria and 5 (26.32%) strains of gram-negative bacteria.The multivariate logistic regression analysis indicated that the independent risk factors for the postoperative infections in the patients undergoing artificial hip replacement surgery included the advanced age, long operation duration, long drainage time, low level of albumin, history of hip surgery, and complication of diabetic mellitus (P＜0.05). CONCLUSION The gram-positive bacteria are dominant among the pathogens causing the postoperative surgical site infections in the patients undergoing the artificial hip replacement surgery.There are a variety of influencing factors for the surgical site infections.It is necessary for the hospital to take corresponding prevention measures.