Abstract: OBJECTIVE To investigate the risk factors for nosocomial infections in hospitalized patients of psychiatrics department so as to provide scientific basis for effective prevention of the nosocomial infections. METHODS The clinical data of 534 patients who were hospitalized the department of psychiatrics from Jan 2014 to Jun 2015 were retrospectively investigated, the statistical analysis of data was performed by using SPSS19.0 software, and the no-conditional multivariate logistic regression analysis was carried out. RESULTS The nosocomial infections occurred in 55 of 534 patients, with the infection rate 10.30%; the patients with respiratory tract infections were dominant, accounting for 58.18%.A total of 48 strains of pathogens were isolated, of which 43.75% were Klebsiella pneumoniae, 22.91% were Escherichia coli, and 16.67% were Staphylococcus aureus.The univariate analysis showed that the risk factors for the nosocomial infections included the more than 60 years of age, schizophrenia, no less than 2 times of hospitalization, complications with other diseases, use of antibiotics, protective constraint, high PANSS score, and high score of antipsychotic drug-induced adverse reactions (P＜0.05).The non-conditional multivariate logistic regression analysis indicated that the independent risk factors for the nosocomial infections included the schizophrenia, no less than 2 times of hospitalization, use of no less than 2 types of antipsychotic drugs, complications of diabetic mellitus, use of no less than 2 types of antibiotics, protective constraint, high PANSS score, and score of antipsychotic drug-induced adverse reactions (P＜0.05). CONCLUSION There are a variety of risk factors for the nosocomial infections in the hospitalized patients of psychiatrics department, and it is necessary to take the intervention measures.