Abstract: OBJECTIVE To observe the clinical effect of subcutaneous tunnel gallbladder bile duct angioplasty on treatment of hepatolithiasis complicated with infections so as to provide guidance for clinical treatment of hepatolithiasis complicated with infections. METHODS A total of 108 hepatolithiasis patients complicated with infections were enrolled in the study and divided into the observation group and the control group, with 54 cases in each group. The control group was treated with conventional surgical procedures, while the observation group was given subcutaneous tunnel gallbladder bile duct angioplasty. The effective rate of treatment was observed and compared between the two groups, and the statistical analysis of data was performed with the use of SPSS 16.0 software. RESULTS The effective rate of treatment was 92.59% in the observation group, 77.78% in the control group; the incidence of complications was 12.96% in the observation group, lower than 53.70% in the control group. The one-year follow-up showed that the recurrence rate was 9.26% in the observation group, 22.22% in the control group, and there was significant difference between the two groups (P<0.05). CONCLUSION The subcutaneous tunnel gallbladder bile duct angioplasty can achieve significant clinical effect and effectively reduce the incidence of postoperative complications, with the recurrence rate low, and it is worthy to be promoted in the hospital.