Abstract: OBJECTIVE To explore the risk factors associated with the nosocomial infections in cardiac surgery so as to provide references for the control of nosocomial infections. METHODS A retrospective survey was adopted to investigate the clinical data of 2955 cardiovascular surgical patients from Oct. 2013 to Jun. 2015 collected from RT-NISS. The single and multiple factor regression analyses were performed. RESULTS The nosocomial infections occurred in 117 cases with the infection rate of 3.96%. The single factor analysis showed that large vascular disease, infective endocarditis, hypertension, surgery,ICU admission, respirator, central venous catheterization, use of urinary catheterization and long hospital stay were influencing factors of nosocomial infections in cardiac surgery (P＜0.05). The multiple factor regression analysis showed that large vascular disease, hypertension, respirator, long hospital stay were the independent risk factors for the infections (P＜0.10). CONCLUSION In clinical work, it is necessary to protect patients with large vascular disease, hypertension, respirator and long hospital stay, so as to decrease the nosocomial infection rate.