Abstract: OBJECTIVE To explore the programs of clinical treatment of patients with septic shock induced by gastrointestinal tract infections and analyze the clinical efficacy so as to provide guidance for clinical treatment. METHODS A total of 48 septic shock patients with gastrointestinal tract infections who were treated in hospitals from Jan 2012 to Jun 2015 were enrolled in the study and randomly divided into the observation group and the control group, with 24 cases in each group, and the clinical data of the patients were analyzed. The observation group was treated with dopamine combined with norepinephrine, while the control group was given norepinephrine. The hemodynamic parameters and oxygenation indicators of the two groups of patients were observed after the treatment, and the clinical efficacy was analyzed. RESULTS There was no significant difference in the mean arterial pressure between the two groups of patients. The heart rate of the observation group was significantly lower than that of the control group. The pulmonary artery wedge pressure, cardiac index, systemic vascular resistance index, and left ventricular stroke work index were significantly higher in the observation group than in the control group(P<0.05). The oxygen consumption of the observation group was significantly lower than that of the control group, and the oxygen uptake rate was remarkably high (P<0.05). The level of lactate was (3.69±1.96)mmol/L in the observation group, (4.58±2.52)mmol/L in the control group, and dopamine combined with norepinephrine could effectively reduce the level of lactate of the patients. CONCLUSION Dopamine combined with norepinephrine can effectively improve the symptom of septic shock, and it is worthy to be promoted in the hospital.