Abstract: OBJECTIVE To study the effect of telmisartan on protection of myocardia of mice with viral myocarditis and its mechanism so as to alleviate the myocardial injury and avoid the development of dilated cardiomyopathy. METHODS A total of 70 mice were recruited as the experiment objects and randomly divided into the observation group with 30 mice, the control group with 30 mice, and the blank group with 10 mice. The observation group and the control group were treated with abdominal injection of coxsackie B3 virus so as to establish the myocarditis mice model, the mice in the observation group were fed with telmisartan from the date when they had the viral infection, for 7 consecutive days; the control group was not given any drug intervention; the mice in the blank group were treated with abdominal injection of equal amount of phosphate buffer but were not given drug intervention. The myocardial pathologic histology integral, concentrations of serum adiponectin, cardiac troponin I (cTn I),and BNP as well as concentrations of tumor necrosis factor alpha and interleukin-6 in myocardial homogenates were observed and compared among the three groups. RESULTS The level of serum adiponectin of the observation group was significantly higher than that of the control group, however, the levels of tumor necrosis factor alpha and interleukin-6 in myocardial homogenates, the levels of serum cardiac troponin Ⅰ and BNP, and pathologic integral were lower in the observation group than in the control group, and there was significant difference (P<0.05); as compared with the blank group, the level of serum adiponectin of the control group was reduced, while the levels of interleukin-6, tumor necrosis factor alpha, troponin Ⅰ and BNP, and pathologic integral were significantly elevated, and there was significant difference (P<0.05). CONCLUSION Telmisartan can alleviate myocardial injuryinduced by the viral myocarditis and has certain effect on protection of hearts, and its mechanism may be associated with the elevated level of serum adiponectin, or the reduced levels of inflammatory factors such as