Abstract: OBJECTIVE To analyze risk factors and clinical features of hospital infections in endocrinology inpatients, so as to provide references for its prevention and treatment. METHODS Clinical data of 989 cases of endocrinology inpatient patients from Sept.2013 to Apr.2015 our hospital were retrospectively analyzed, and associated risk factors and clinical features were analyzed. RESULTS There were 71 cases of infections in 989 patients, with the infection rate of 7.18%. Factors including age, diabetes and the length of time patients had close relationship with infections, patients with diabetes had higher incidence of hospital infections. In addition, the hospital hygienic environment and daily regulations also had a certain effect on infection rate. Among 65 strains of pathogenic bacteria, 44 strains were gram-negative bacteria, accounting for 67.69%, and 21 strains were gram-positive bacteria, accounting for 32.31%. Gram-negative bacteria were mainly Escherichia coli, Proteus and Klebsiella, accounting for 32.31%, 20.00%, and 15.38%, respectively.Gram-positive bacteria were mainly Enterococcus and Epidermis staphylococcus. The clinical manifestations were mainly in respiratory tract and urinary tract in 71 cases of infected patients, accounting for 45.06% and 40.85% respectively. CONCLUSION Endocrinology patients have a high incidence of hospital infections. Patients' age, disease properties, and the length of time were the main risk factors of hospital infections. Clinical pathogenic bacteria are widely distributed, mainly Escherichia coli, Proteus and Klebsiella. Clinical manifestations of sites are mainly respiratory tract and urinary tract infection. It needs to actively take effective measures to reduce hospital infection rates.