Abstract: OBJECTIVE To explore the correlation between IL-2, IL-6 and liver function, hepatitis C virus RNA levels and liver function. METHODS From Jan. 2014 to Sep. 2015, 57 patients with hepatitis C in our hospital were chosen as study objects. They were divided into no obvious clinical symptom group with 23 cases, moderate severe group with 19 cases and severe group with 15 cases according to clinical condition. Totally 28 healthy people were selected as control group. Fasting blood of the three groups of patients were collected to test liver function and serum IL-2 and IL-6 levels. Fluorogenic probe quantitative reverse transcription polymerase chain reaction was conducted to detect HCV-RNA level. RESULTS Patients without significant symptoms had similar serum IL-2 and Il-6 levels to the control group. The differences had no significantly significance (P>0.05). But serum IL-2 contents of patients with mild and severe liver cirrhosis infection were notably lower than the control group (P＜0.05); the serum IL-6 contents of patients with moderate and severe liver cirrhosis were significantly higher than patients in the control group (P＜0.05). ALT, AST, TBIL and DBIL levels of patients with hepatitis C were significantly higher than the normal control group (P<0.05). Serum IL-2 and IL-6 levels were not significantly correlated to HCV-ENA. CONCLUSION As hepatitis C worsen, serum IL-2 levels increase and IL-6 decrease. The condition of the disease have no correlation with HCV-RNA level.