Abstract: OBJECTIVE To investigate the correlation of preoperative nutritional, glucocorticoids application and postoperative infection in patients with Crohn's disease (CD), so as to provide reference for CD postoperative infectious prevention. METHODS A total of 103 cases of patients from Jan. 2010 to Jun. 2015 in the hospital diagnosed as CD line during bowel resection anastomosis operation were collected, and divided into 58 cases of malnutrition group and 45 cases of normal nutrition group, according to the preoperative nutritional status, and 29 cases of glucocorticoid group and 74 cases of no glucocorticoid group, according to the preoperative glucocorticoid usage. The postoperative infectious complications were analyzed. RESULTS There were 26 cases of infections, with the infection rate of 25.24%. The infection sites were 12 cases of incision infection, 8 cases of infectious abdominal distension diarrhoea, 2 cases of abdominal abscess, 2 cases of infectious anastomotic fistula, and 1 case of lung infection and 1 case of sepsis, accounting for 46.15%, 30.77%, 7.69%, 7.69%, 3.85%, and 3.85%, respectively. There were 6 cases of infections in normal nutrition group, with the infection rate of 13.33%,and 20 cases of infections in malnutrition group, with the infection rate of 34.48%, and the difference was significant (P<0.05). There were 14 cases of infection in no glucocorticoid group, with the infection rate of 18.92%, and 12 cases of infection in glucocorticoid group, with the infection rate of 41.38%, and the difference was significant (P<0.05). CONCLUSION Preoperative nutrition and glucocorticoids application with CD was closely related to postoperative infection, preoperative malnutrition and with use of glucocorticoid treatment significantly increased the risk of postoperative infections.