Abstract: OBJECTIVE To analyze the risk factors associated with percutaneous coronary intervention in patients with hospital infection and discuss the clinical prevention and control strategies, so as to provide the basis for clinical control of PCI hospital infections. METHODS A total of 980 patients treated with PCI were selected in the hospital from Jan. 2010 to Nov. 2015, including 32 infection cases. The infection rate, infection sites, and pathogen types were retrospectively analyzed, and the infection-related factors including genders, age, with chronic diseases, cardiac function classification, puncture sites, the number of stents implanted, other invasive procedures and hospitalization time were analyzed. RESULTS The Infection rate of the patients with PCI was 3.27%.The infection sites were respiratory system 43.75%, urinary system 25.00%, gastrointestinal tract 18.75%, and puncture sites 12.50%, respectively. The constituent ratio of the infected pathogens of PCI patients were G⁺ 53.13%, G^-37.50% and fungi 9.38%.The infection rates of PCI patients with the age ≥60 years, basic diseases≥3, NYHA functional classification (3 to 4), the number of stents implanted in ≥2, invasive procedures and hospitalization time ≥15d were 6.74%,7.75%, 7.01%,3.99%,7.14%, and 6.84%,respectively, which were significantly higher than other patients (P<0.05). CONCLUSION The PCI infection are mainly with respiratory and urinary tract, and its infection rate is related to many factors, so it needs clinical prevention and control to reduce the incidence of infections.