Abstract: OBJECTIVE To explore the distribution and drug resistance of pathogens causing recurrent respiratory tract infections in children so as to provide guidance for reasonable clinical use of antibiotics. METHODS A total of 253 children with recurrent respiratory tract infections who were treated in the hospital from Jan 2013 to Dec 2014 were enrolled in the study. The nasopharyngeal secretions were cultured for pathogens, the isolated pathogens were identified, the drug susceptibility testing was carried out, and the statistical analysis was performed for the drug resistance by using SPSS17.0 software. RESULTS Totally 1 516 strains of pathogens were isolated from the children with recurrent respiratory tract infections, including 1 104 (72.82%) strains of gram-negative bacteria and 412 (27.18%) strains of gram-positive bacteria; the Haemophilus influenzae, Pseudomonas aeruginosa, and Escherichia coli were the gram-negative bacteria, accounting for 22.69%, 13.32%, and 11.48%, respectively; the Staphylococcus aureus and Streptococcus pneumoniae were the major species of gram-positive bacteria, accounting for 14.45% and 5.54%, respectively. The drug resistance rates of P.aeruginosa to cefotetan and cefuroxime were 91.58% and 83.66%, respectively; the drug resistance rate of E.coli to cefuroxime was 46.55%; the drug resistance rates of S.pneumoniae and S.aureus to penicillin were 88.10% and 94.98%, respectively. CONCLUSION The gram-negative bacteria are dominant among the pathogens causing the recurrent respiratory tract infections in the children, and there is a certain individual difference. It is necessary to further improve the reasonable use of antibiotics.