Abstract: OBJECTIVE To investigate the distribution of pathogens causing pulmonary infections in tuberculosis patients and analyze the drug resistance to commonly used antibiotics so as to provide guidance for reasonable use of antibiotics for treatment of the infections. METHODS The clinical data of 157 tuberculosis patients complicated with pulmonary infections who were treated in the hospital from Jan 2013 to Aug 2015 were retrospectively analyzed, the pathogens were identified by using VITEK-32 automatic microorganism identification analysis system and supporting reagents, and the drug susceptibility testing was performed with the use of K-B disk diffusion method. RESULTS A total of 182 strains of pathogens were isolated, including 111 (61.0%) strains of gram-negative bacteria, 64 (35.2%) strains of gram-positive bacteria, and 7 (3.8%) strains of fungi. The drug resistance rates of the Pseudomonas aeruginosa to ampicillin and gentamicin were 100.00%; the drug resistance rates to ceftazidime, cefoperazone, and cefepime were more than 50.0%. The drug resistance rates of the Klebsiella pneumoniae to ceftazidime and cefoperazone were more than 50.0%. The drug resistance rates of the Streptococcus pneumoniae to penicillin G, levofloxacin, and ciprofloxacin were more than 50.0%. The drug resistance rate of the Staphylococcus aureus to penicillin G was 100.0%; the drug resistance rates to erythromycin, gentamicin, and tetracycline were no less than 50.0%. CONCLUSION The gram-negative bacteria are dominant among the pathogens causing the pulmonary infections in the tuberculosis patients; the pathogens causing the infections are highly resistant to a variety of antibiotics. It is necessary for the hospital to reasonably use antibiotics based on the results of the drug susceptibility testing.