Abstract: OBJECTIVE To explore the distribution and drug resistance of pathogens causing postoperative infections in drug abortion patients undergoing curettage so as to provide guidance for clinical prevention and treatment of the postoperative infections in the patients undergoing curettage. METHODS A total of 120 drug abortion patients who underwent the curettage in the hospital from Jan 2011 to Jun 2015 and were complicated with postoperative infections were recruited as the study objects, then the distribution of the pathogens causing the infections were observed, and the drug resistance of the pathogens was analyzed. RESULTS Totally 178 strains of pathogens were isolated from the 120 patients, including 38 (21.35%) strains of gram-positive bacteria and 140 (78.65%) strains of gram-negative bacteria; the Staphylococcus aureus and Enterococcus faecalis were dominant among the gram-positive bacteria; the Escherichia coli, Shigella flexneri, and Salmonella spp dominated among the gram-negative bacteria. The drug susceptibility rates of the E.coli, S.flexneri, Salmonella spp, Klebsiella pneumoniae, and Pseudomonas aeruginosa to meropenem and imipenem were 100.00%; the drug susceptibility rates to aztreonam, cefepime, and cefoxitin were more than 80.00%. The drug resistance rates of the E.faecalis and S.aureus to penicillin, oxacillin, erythromycin, gentamicin, and levofloxacin were more than 40.00%. CONCLUSION The pathogens causing the postoperative infections in the curettage patients are highly drug-resistant. It is necessary to conduct the early empirical drug therapy based on clinical experience so as to reasonably use antibiotics.