Abstract: OBJECTIVE To investigate the effect of Helicobacter pylori (Hp) infection in patients with coronary heart disease related indicators, blood lipid and carotid atherosclerosis, and to analyze the possible mechanism of the impact of Hp infection on carotid atherosclerotic coronary heart disease. METHODS A total of 200 cases of patients with coronary heart disease were selected from Aug. 2014 to Aug. 2015 in our hospital, and they were divided into Hp infection group and non-Hp infection group with 100 patients in each group. The changes of serum hs-CRP, UA, FIB, oxLDL, blood lipid and the ultrasound presence of carotid atherosclerosis were detected. RESULTS Hs-CRP, UA, FIB, oxLDL, TC,TG and LDL-C of Hp infection group were higher than that of the non-Hp infection group (P<0.05);Prevalence of carotid atherosclerosis of the Hp infection group was 68.00% which was higher than 53.00% of the non-Hp infection group. Unstable plaque detection rate of the Hp infection group wes 23.00% which was higher than 7.00% of the non-Hp infection group. Intima-media thickness detection rate of the Hp infection group was 11.00% which was lower than 22.00% of the non-Hp infection group. The differences were significant (P<0.05). CONCLUSION The prevalence rates of hs-CRP, UA, FIB, oxLDL, blood lipid levels and carotid arteriosclerosis in Hp infection for patients with coronary heart disease increase significantly, and the conditions for severe infection performance are more apparent. It probably promotes the development and occurrence of carotid sclerosis by influencing the body's inflammatory response and lipid metabolism after Hp infection.