Abstract: OBJECTIVE To analyze the distribution of pathogens causing infections in type Ⅱ diabetic patients with dialysis therapy and to discuss the influence of infections on kidney functions so as to provide reference for clinical treatments. METHODS From May 2008 to Nov. 2014, 92 infected cases in our hospital with type Ⅱ diabetes and received dialysis therapy were chosen as infection group. The infected pathogens were identified by PHOENIX TM100 and the serum creatinine, urea nitrogen, urine microalbumin, CysC, NT-proBNP, CRP and ET levels were detected by ELISA. Totally 110 cases of healthy subjects and 100 cases of non-infected patients were taken as control at the same period in our hospital. RESULTS Totally 110 stains of pathogens were identified from the 92 patients. The pathogens contained 59 (53.6%) gram-positive strains, mainly including 16 strains of Staphylococcus epidermidis (14.5%) and 51 (46.4%) gram-negative strains, mainly including 13 strains of Acinetobacter baumannii (11.8%). The results also revealed that the serum Scr, BUN and micro-albuminuria were increased greatly in infected patients and the differences were significant (P<0.01). The results also showed that the serum endothelin, CysC, NT-proBNP and CRP were increased significantly in infected patients (P<0.01). CONCLUSION Type Ⅱ diabetic patients with dialysis are easy to suffer from pathogen infections and the infection can lead to increased endothelin, CysC, NT-proBNP and CRP and therefore, kidney disfunction.