Abstract: OBJECTIVE To evaluate the use of conservative treatment on patients with cardiovascular implantable electronic device pocket infection so as to provide theoretical guidance and reference for treating pocket infection. METHODS From Feb. 2008 to Sep. 2013, 14 cases of patients with the treatment of cardiovascular implantable electronic devices and got capsular bag infection were selected as study objects. Among them, 9 patients who did not remove a full-pacing system were regarded as the observation group. Other 5 cases as the control group had their full set of pacing system and infected capsular bag removed and new set was replanted in the opposite side. The pathogen types, clearance times, recurrence of infection and effective rate after first clearance were observed and recorded in details. All data were statistically analyzed by SPSS 21.0. RESULTS The effective rate after first clearance of the observation group was 33.34%. Among them, 6 cases had good prognosis and received the second clearance, and 2 cases relapsed and received several clearance. In the control group, 4 cases had good prognosis and the effective rate of first clearance was 80.00%. Only one case got relapsed and turned well after the second clearance. No infection reappeared. Gram-positive bacteria, mainly including Staphylococcus aureus and Staphylococcus epidermidis, were proved to be the major pathogens, followed by gram-negative bacteria. CONCLUSION Local clearance, washing with antibiotics, rational placement of heart pacemaker and anti-infection treatment have certain effect on controlling infection in CIED pocket-infected patients.